Homo sapiens Gene: AGXT
Summary
InnateDB Gene IDBG-84952.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol AGXT
Gene Name alanine-glyoxylate aminotransferase
Synonyms AGT; AGT1; AGXT1; PH1; SPAT; SPT; TLH6;
Species Homo sapiens
Ensembl Gene ENSG00000172482
Encoded Proteins
alanine-glyoxylate aminotransferase
Protein Structure
Entrez Gene
Summary This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:241807896-241819919
Strand Forward strand
Band q37.3
Transcripts
ENST00000307503 ENSP00000302620
ENST00000472436
ENST00000476698
ENST00000470255
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004760 serine-pyruvate transaminase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008453 alanine-glyoxylate transaminase activity
GO:0008483 transaminase activity
GO:0016597 amino acid binding
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006625 protein targeting to peroxisome
GO:0008152 metabolic process
GO:0009436 glyoxylate catabolic process
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
GO:0019448 L-cysteine catabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042853 L-alanine catabolic process
GO:0042866 pyruvate biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046487 glyoxylate metabolic process
GO:0046724 oxalic acid secretion
GO:0051384 response to glucocorticoid stimulus
GO:0051591 response to cAMP
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Glyoxylate metabolism pathway
KEGG
Glycine, serine and threonine metabolism pathway
Alanine, aspartate and glutamate metabolism pathway
Metabolic pathways pathway
Peroxisome pathway
INOH
Alanine Aspartate Asparagine metabolism pathway
Glycolysis Gluconeogenesis pathway
Glycine Serine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P21549
TrEMBL
UniProt Splice Variant
Entrez Gene 189
UniGene Hs.144567
RefSeq NM_000030
HUGO 341
OMIM 604285
CCDS CCDS2543
HPRD 05048
IMGT
EMBL AC104809 AK292754 BC132819 CH471063 D13368 M61763 X53414 X56092
GenPept AAA51680 AAI32820 AAY24168 BAA02632 BAF85443 CAA37493 CAA39572 EAW71222
ImmGen AGXT (murine)
RNA Seq Atlas 189