Homo sapiens Gene: AGXT

Summary
InnateDB Gene IDBG-84952.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol AGXT
Gene Name alanine-glyoxylate aminotransferase
Synonyms AGT; AGT1; AGXT1; PH1; SPAT; SPT; TLH6
Species Homo sapiens
Ensembl Gene ENSG00000172482
Encoded Proteins
IDBP-84954 alanine-glyoxylate aminotransferase
Entrez Gene
Summary This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2: 241807896-241819919
Strand Forward strand
Band q37.3
Transcripts
ENST00000307503  ENSP00000302620
ENST00000472436 
ENST00000476698 
ENST00000470255 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein‑Protein  8
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0004760 serine-pyruvate transaminase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008453 alanine-glyoxylate transaminase activity
GO:0008483 transaminase activity
GO:0016597 amino acid binding
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006625 protein targeting to peroxisome
GO:0008152 metabolic process
GO:0009436 glyoxylate catabolic process
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
GO:0019448 L-cysteine catabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042853 L-alanine catabolic process
GO:0042866 pyruvate biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046487 glyoxylate metabolic process
GO:0046724 oxalic acid secretion
GO:0051384 response to glucocorticoid stimulus
GO:0051591 response to cAMP
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000026272 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000005797 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_16925 Glyoxylate metabolism
KEGG
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00260  Glycine, serine and threonine metabolism
hsa01100  Metabolic pathways
hsa04146  Peroxisome
INOH
INOH website Alanine Aspartate Asparagine metabolism
INOH website Glycine Serine metabolism
INOH website Glycolysis Gluconeogenesis
PID BIOCARTA
PID NCI
Cross-References
SwissProt P21549 
TrEMBL
UniProt Splice Variant
Entrez Gene 189 
UniGene Hs.144567
RefSeq NM_000030 
HUGO 341 
OMIM 604285
CCDS CCDS2543 
HPRD 05048
IMGT
EMBL AC104809 AK292754 BC132819 CH471063 D13368 M61763 X53414 X56092
GenPept AAA51680  AAI32820  AAY24168  BAA02632  BAF85443  CAA37493  CAA39572  EAW71222 
ImmGen AGXT (murine) 
RNA Seq Atlas 189