Homo sapiens Protein: PASK | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-85030.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | PASK | ||||||||||||||||||||||
Protein Name | PAS domain containing serine/threonine kinase | ||||||||||||||||||||||
Synonyms | PASKIN; STK37; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000234040 | ||||||||||||||||||||||
InnateDB Gene | IDBG-85028 (PASK) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation. {ECO:0000269PubMed:16275910, ECO:0000269PubMed:17052199, ECO:0000269PubMed:17595531, ECO:0000269PubMed:20943661, ECO:0000269PubMed:21181396, ECO:0000269PubMed:21418524}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:17595531}. Nucleus {ECO:0000269PubMed:17595531}. Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level). | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000014
PAS domain IPR000719 Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR013767 PAS fold IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF13188
PF13426 PF00069 PF07714 PF00989 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||||
SMART |
SM00091
SM00220 SM00219 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q96RG2 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q96RG2 | ||||||||||||||||||||||
TrEMBL | Q14148 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 23178 | ||||||||||||||||||||||
UniGene | Hs.595204 | ||||||||||||||||||||||
RefSeq | NP_055963 | ||||||||||||||||||||||
HUGO | HGNC:17270 | ||||||||||||||||||||||
OMIM | 607505 | ||||||||||||||||||||||
CCDS | CCDS2545 | ||||||||||||||||||||||
HPRD | 06328 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC005237 AF067137 AF387103 AK302561 BC043495 BC050565 BC063585 CH471063 CR749231 D50925 U79240 | ||||||||||||||||||||||
GenPept | AAB50198 AAC23506 AAH43495 AAH50565 AAH63585 AAK69752 BAA09484 BAH13743 CAH18087 EAW71238 | ||||||||||||||||||||||