InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAS1R3

Summary

InnateDB Protein

IDBP-85095.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAS1R3

Protein Name

taste receptor, type 1, member 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000344411

InnateDB Gene

IDBG-85093 (TAS1R3)

Protein Structure

UniProt Annotation

Function

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. {ECO:0000250, ECO:0000269PubMed:11917125, ECO:0000269PubMed:12892531}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008527	taste receptor activity
GO:0033041	sweet taste receptor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001582	detection of chemical stimulus involved in sensory perception of sweet taste
GO:0007186	G-protein coupled receptor signaling pathway
GO:0050916	sensory perception of sweet taste
GO:0050917	sensory perception of umami taste

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000337 GPCR, family 3
IPR001828 Extracellular ligand-binding receptor
IPR011500 GPCR, family 3, nine cysteines domain
IPR017978 GPCR, family 3, C-terminal
IPR028082 Periplasmic binding protein-like I
IPR029040 RNA polymerase subunit RPABC4/transcription elongation factor Spt4

PFAM

PF01094
PF07562
PF00003

PRINTS

PR00248

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7RTX0