InnateDB Protein
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IDBP-85229.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MAPKAP1
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Protein Name
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mitogen-activated protein kinase associated protein 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000362602
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InnateDB Gene
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IDBG-85219 (MAPKAP1)
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Protein Structure
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Function |
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. {ECO:0000269PubMed:15988011, ECO:0000269PubMed:16962653, ECO:0000269PubMed:17043309, ECO:0000269PubMed:17054722, ECO:0000269PubMed:17303383, ECO:0000269PubMed:23727834}.
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Subcellular Localization |
Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed, with highest levels in heart and skeletal muscle. {ECO:0000269PubMed:15988011}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
54
[view]
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Protein-Protein |
54
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
GO:0007173
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epidermal growth factor receptor signaling pathway
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GO:0008543
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fibroblast growth factor receptor signaling pathway
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GO:0021762
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substantia nigra development
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GO:0031295
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T cell costimulation
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GO:0038095
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Fc-epsilon receptor signaling pathway
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GO:0045087
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innate immune response
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GO:0046580
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negative regulation of Ras protein signal transduction
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GO:0048011
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neurotrophin TRK receptor signaling pathway
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GO:0048015
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phosphatidylinositol-mediated signaling
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Cellular Component |
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PDB ID |
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InterPro |
IPR008828
Stress-activated map kinase interacting 1
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PFAM |
PF05422
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BPZ7
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PhosphoSite |
PhosphoSite-Q9BPZ7
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TrEMBL |
B1AMA6
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UniProt Splice Variant |
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Entrez Gene |
79109
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UniGene |
Hs.629072
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RefSeq |
NP_001006621
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HUGO |
HGNC:18752
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OMIM |
610558
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CCDS |
CCDS35141
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HPRD |
17464
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IMGT |
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EMBL |
AK290060
AK295364
AK316149
AL162584
AL358074
AL359632
AL833042
AY524429
AY524430
AY524431
AY524432
AY633624
AY633625
AY633626
BC002326
BC003044
CH471090
M37191
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GenPept |
AAA36551
AAH02326
AAH03044
AAS90839
AAS90840
AAS90841
AAS90842
AAT46478
AAT46479
AAT46480
BAF82749
BAH12045
BAH14520
CAH56311
CAI39500
CAI39506
CAI39507
CAI39888
CAI39891
CAI39892
EAW87630
EAW87631
EAW87632
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