InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAPKAP1

Summary

InnateDB Protein

IDBP-85231.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPKAP1

Protein Name

mitogen-activated protein kinase associated protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362597

InnateDB Gene

IDBG-85219 (MAPKAP1)

Protein Structure

UniProt Annotation

Function

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. {ECO:0000269PubMed:15988011, ECO:0000269PubMed:16962653, ECO:0000269PubMed:17043309, ECO:0000269PubMed:17054722, ECO:0000269PubMed:17303383, ECO:0000269PubMed:23727834}.

Subcellular Localization

Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with highest levels in heart and skeletal muscle. {ECO:0000269PubMed:15988011}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	54 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0017016	Ras GTPase binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
GO:0070300	phosphatidic acid binding
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0021762	substantia nigra development
GO:0031295	T cell costimulation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0046580	negative regulation of Ras protein signal transduction
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling