Version 5.4
Homo sapiens Protein: CREG1
Summary
InnateDB Protein IDBP-85271.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CREG1
Protein Name cellular repressor of E1A-stimulated genes 1
Synonyms CREG;
Species Homo sapiens
Ensembl Protein ENSP00000359540
InnateDB Gene IDBG-104554 (CREG1)
Protein Structure
UniProt Annotation
Function May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R. {ECO:0000269PubMed:12934103, ECO:0000269PubMed:9710587}.
Subcellular Localization Secreted {ECO:0000269PubMed:10815803}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0008134 transcription factor binding
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0008283 cell proliferation
GO:0040008 regulation of growth
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005667 transcription factor complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR012349 FMN-binding split barrel
IPR014631 Cellular repressor of E1A-stimulated genes (CREG)
PFAM
PRINTS
PIRSF PIRSF036911
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75629
PhosphoSite PhosphoSite-O75629
TrEMBL
UniProt Splice Variant
Entrez Gene 8804
UniGene Hs.5710
RefSeq NP_003842
HUGO HGNC:2351
OMIM
CCDS CCDS1262
HPRD 09897
IMGT
EMBL AF084523 AK095456 AK315497 AL031733 AY359071 BC006786 BC008628 CH471067
GenPept AAC34861 AAH06786 AAH08628 AAQ89430 BAC04550 BAG37881 CAB42866 EAW90795

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca