Version 5.4
Homo sapiens Gene: CREG1
Summary
InnateDB Gene IDBG-104554.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CREG1
Gene Name cellular repressor of E1A-stimulated genes 1
Synonyms CREG
Species Homo sapiens
Ensembl Gene ENSG00000143162
Encoded Proteins
IDBP-85271
cellular repressor of E1A-stimulated genes 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:167529677-167553767
Strand Reverse strand
Band q24.2
Transcripts
ENST00000370509 ENSP00000359540
ENST00000466652
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0008134 transcription factor binding
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0008283 cell proliferation
GO:0040008 regulation of growth
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005667 transcription factor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040713
View Gene Order
ENSBTAG00000008931
Not yet available
Cross-References
SwissProt O75629
TrEMBL
UniProt Splice Variant
Entrez Gene 8804
UniGene Hs.5710
RefSeq NM_003851
HUGO HGNC:2351
OMIM
CCDS CCDS1262
HPRD 09897
IMGT
EMBL AF084523 AK095456 AK315497 AL031733 AY359071 BC006786 BC008628 CH471067
GenPept AAC34861 AAH06786 AAH08628 AAQ89430 BAC04550 BAG37881 CAB42866 EAW90795
RNA Seq Atlas 8804

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca