Version 5.4
Homo sapiens Protein: DTYMK
Summary
InnateDB Protein IDBP-85278.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DTYMK
Protein Name deoxythymidylate kinase (thymidylate kinase)
Synonyms CDC8; PP3731; TMPK; TYMK;
Species Homo sapiens
Ensembl Protein ENSP00000304802
InnateDB Gene IDBG-85276 (DTYMK)
Protein Structure
UniProt Annotation
Function Catalyzes the conversion of dTMP to dTDP.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0050145 nucleoside phosphate kinase activity
Biological Process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0007049 cell cycle
GO:0008283 cell proliferation
GO:0009165 nucleotide biosynthetic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0043627 response to estrogen
GO:0044281 small molecule metabolic process
GO:0045445 myoblast differentiation
GO:0046686 response to cadmium ion
GO:0046939 nucleotide phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR018094 Thymidylate kinase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P23919
PhosphoSite PhosphoSite-P23919
TrEMBL Q6FGU2
UniProt Splice Variant
Entrez Gene 1841
UniGene
RefSeq NP_036277
HUGO HGNC:3061
OMIM 188345
CCDS CCDS2552
HPRD 01773
IMGT
EMBL AC133528 BC001827 BC147006 BC147010 BC171902 CH471063 CR541986 CR542015 L16991 X54729
GenPept AAA21719 AAH01827 AAI47007 AAI47011 AAI71902 AAY14920 CAA38528 CAG46783 CAG46812 EAW71284

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca