InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ING5

Summary

InnateDB Protein

IDBP-85290.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ING5

Protein Name

inhibitor of growth family, member 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000322142

InnateDB Gene

IDBG-85288 (ING5)

Protein Structure

UniProt Annotation

Function

Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. {ECO:0000269PubMed:12750254, ECO:0000269PubMed:16387653}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18794358}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.

Experimentally validated
Total	47 [view]
Protein-Protein	47 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0035064	methylated histone binding

Biological Process

GO:0006260	DNA replication
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006473	protein acetylation
GO:0008285	negative regulation of cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0043966	histone H3 acetylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045926	negative regulation of growth
GO:2001235	positive regulation of apoptotic signaling pathway