Version 5.4
Homo sapiens Gene: ING5
Summary
InnateDB Gene IDBG-85288.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ING5
Gene Name inhibitor of growth family, member 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168395
Encoded Proteins
IDBP-85290
inhibitor of growth family, member 5
IDBP-292373
inhibitor of growth family, member 5
IDBP-389727
inhibitor of growth family, member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:241702035-241729478
Strand Forward strand
Band q37.3
Transcripts
ENST00000313552 ENSP00000322142
ENST00000406941 ENSP00000385937
ENST00000445620 ENSP00000416878
ENST00000492488
ENST00000482774
ENST00000493261
ENST00000489509
ENST00000484145
ENST00000493578
ENST00000474238
ENST00000486061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035064 methylated histone binding
Biological Process
GO:0006260 DNA replication
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006473 protein acetylation
GO:0008285 negative regulation of cell proliferation
GO:0016573 histone acetylation
GO:0043065 positive regulation of apoptotic process
GO:0043966 histone H3 acetylation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045926 negative regulation of growth
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0070776 MOZ/MORF histone acetyltransferase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026283
View Gene Order
ENSBTAG00000009123
Not yet available
Pathways
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.529172 Hs.645460 Hs.667169
RefSeq NM_032329 XM_005247047
HUGO
OMIM
CCDS CCDS33425
HPRD 16348
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca