InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NTSR1

Summary

InnateDB Protein

IDBP-85312.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTSR1

Protein Name

neurotensin receptor 1 (high affinity)

Synonyms

NTR;

Species

Homo sapiens

Ensembl Protein

ENSP00000359532

InnateDB Gene

IDBG-85310 (NTSR1)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis. {ECO:0000269PubMed:21725197, ECO:0000269PubMed:23140271, ECO:0000269PubMed:8381365}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Membrane raft. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts.

Disease Associations

Tissue Specificity

Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain. {ECO:0000269PubMed:20048080, ECO:0000269PubMed:8381365}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016492	G-protein coupled neurotensin receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0008344	adult locomotory behavior

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR003984 Neurotensin receptor
IPR003985 Neurotensin type 1 receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019426 7TM GPCR, serpentine receptor class v (Srv)

PFAM

PF00001
PF10323

PRINTS

PR00237
PR01479
PR01480

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30989