Version 5.4
Homo sapiens Gene: NTSR1
Summary
InnateDB Gene IDBG-85310.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NTSR1
Gene Name neurotensin receptor 1 (high affinity)
Synonyms NTR
Species Homo sapiens
Ensembl Gene ENSG00000101188
Encoded Proteins
IDBP-85312
neurotensin receptor 1 (high affinity)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:62708837-62762771
Strand Forward strand
Band q13.33
Transcripts
ENST00000370501 ENSP00000359532
ENST00000482259
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0016492 G-protein coupled neurotensin receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007268 synaptic transmission
GO:0008344 adult locomotory behavior
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027568
View Gene Order
ENSBTAG00000021727
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P30989
TrEMBL
UniProt Splice Variant
Entrez Gene 4923
UniGene Hs.590869
RefSeq NM_002531
HUGO HGNC:8039
OMIM 162651
CCDS CCDS13502
HPRD 01218
IMGT
EMBL AL035669 AL357033 AY429106 X70070
GenPept AAR07901 CAA49675 CAC12747 CAC14923
RNA Seq Atlas 4923

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca