Version 5.4
Homo sapiens Protein: GAL3ST2
Summary
InnateDB Protein IDBP-85323.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAL3ST2
Protein Name galactose-3-O-sulfotransferase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000192314
InnateDB Gene IDBG-85321 (GAL3ST2)
Protein Structure
UniProt Annotation
Function Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal- beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency.
Subcellular Localization Golgi apparatus, Golgi stack membrane {ECO:0000305PubMed:11029462}; Single-pass type II membrane protein {ECO:0000305PubMed:11029462}.
Disease Associations
Tissue Specificity Ubiquitous. Detected in heart, stomach, colon, liver and spleen, in epithelial cells lining the lower to middle layer of the crypts in colonic mucosa, hepatocytes surrounding the central vein of the liver, extravillous cytotrophoblasts in the basal plate of the septum of the placenta, renal tubules of the kidney, and neuronal cells of the cerebral cortex. {ECO:0000269PubMed:11029462}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001733 galactosylceramide sulfotransferase activity
GO:0008146 sulfotransferase activity
Biological Process
GO:0008150 biological_process
GO:0009058 biosynthetic process
Cellular Component
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
Protein Structure and Domains
PDB ID
InterPro IPR009729 Galactose-3-O-sulfotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF06990
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H3Q3
PhosphoSite PhosphoSite-Q9H3Q3
TrEMBL
UniProt Splice Variant
Entrez Gene 64090
UniGene Hs.632556
RefSeq NP_071417
HUGO HGNC:24869
OMIM 608237
CCDS CCDS33427
HPRD 16303
IMGT
EMBL AB040610 AC114730 BC117293 BC117295 CH471063
GenPept AAI17294 AAI17296 AAX82021 BAB16844 EAW71293

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca