InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDCD1

Summary

InnateDB Protein

IDBP-85348.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDCD1

Protein Name

programmed cell death 1

Synonyms

CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2;

Species

Homo sapiens

Ensembl Protein

ENSP00000335062

InnateDB Gene

IDBG-85346 (PDCD1)

Protein Structure

UniProt Annotation

Function

Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors. {ECO:0000269PubMed:21276005}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Systemic lupus erythematosus 2 (SLEB2) [MIM:605218]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269PubMed:12402038}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006959	humoral immune response
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0031295	T cell costimulation
GO:0045087	innate immune response (InnateDB)