InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMARCA1

Summary

InnateDB Protein

IDBP-85464.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMARCA1

Protein Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

Synonyms

ISWI; NURF140; SNF2L; SNF2L1; SNF2LB; SNF2LT; SWI; SWI2;

Species

Homo sapiens

Ensembl Protein

ENSP00000360162

InnateDB Gene

IDBG-85456 (SMARCA1)

Protein Structure

UniProt Annotation

Function

Energy-transducing component of NURF (nucleosome- remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells. {ECO:0000269PubMed:14609955, ECO:0000269PubMed:15310751, ECO:0000269PubMed:15640247, ECO:0000269PubMed:16740656}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0031491	nucleosome binding
GO:0036310	annealing helicase activity
GO:0070615	nucleosome-dependent ATPase activity

Biological Process

GO:0000733	DNA strand renaturation
GO:0006200	ATP catabolic process
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0007420	brain development
GO:0030182	neuron differentiation
GO:0043044	ATP-dependent chromatin remodeling
GO:0045893	positive regulation of transcription, DNA-templated
GO:2000177	regulation of neural precursor cell proliferation

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0016589	NURF complex
GO:0090537	CERF complex

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR001005 SANT/Myb domain
IPR001650 Helicase, C-terminal
IPR006935 Helicase/UvrB domain
IPR009057 Homeodomain-like
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR015194 ISWI HAND domain
IPR015195 SLIDE domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM