Version 5.4
Homo sapiens Protein: XPNPEP2
Summary
InnateDB Protein IDBP-85633.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XPNPEP2
Protein Name X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
Synonyms AEACEI; APP2;
Species Homo sapiens
Ensembl Protein ENSP00000360147
InnateDB Gene IDBG-85631 (XPNPEP2)
Protein Structure
UniProt Annotation
Function A metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin.
Subcellular Localization Cell membrane; Lipid-anchor, GPI-anchor.
Disease Associations
Tissue Specificity Expressed in kidney, lung, heart, placenta, liver, small intestine and colon. No expression in brain, skeletal muscle, pancreas, spleen, thymus, prostate, testis and ovary.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000587 Creatinase, N-terminal
IPR000994 Peptidase M24, structural domain
IPR028980 Creatinase/Aminopeptidase P, N-terminal
PFAM PF01321
PF00557
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43895
PhosphoSite PhosphoSite-O43895
TrEMBL
UniProt Splice Variant
Entrez Gene 7512
UniGene
RefSeq NP_003390
HUGO HGNC:12823
OMIM 300145
CCDS CCDS14613
HPRD 02144
IMGT
EMBL AF195953 AL023653 BC126174 U90724
GenPept AAB96394 AAG28480 AAI26175 CAA19220

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca