Version 5.4
Homo sapiens Gene: XPNPEP2
Summary
InnateDB Gene IDBG-85631.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XPNPEP2
Gene Name X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
Synonyms AEACEI; APP2
Species Homo sapiens
Ensembl Gene ENSG00000122121
Encoded Proteins
IDBP-85633
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
IDBP-85635
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]
Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the \'pita bread fold\' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:129738974-129769538
Strand Forward strand
Band q26.1
Transcripts
ENST00000371106 ENSP00000360147
ENST00000371105 ENSP00000360146
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0008152 metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037005
View Gene Order
ENSBTAG00000010345
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt O43895
TrEMBL
UniProt Splice Variant
Entrez Gene 7512
UniGene
RefSeq NM_003399
HUGO HGNC:12823
OMIM 300145
CCDS CCDS14613
HPRD 02144
IMGT
EMBL AF195953 AL023653 BC126174 U90724
GenPept AAB96394 AAG28480 AAI26175 CAA19220
RNA Seq Atlas 7512

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca