InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP23B

Summary

InnateDB Protein

IDBP-85655.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP23B

Protein Name

matrix metallopeptidase 23B

Synonyms

MIFR; MIFR-1; MMP22; MMP23A;

Species

Homo sapiens

Ensembl Protein

ENSP00000348308

InnateDB Gene

IDBG-85653 (MMP23B)

Protein Structure

UniProt Annotation

Function

Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Membrane {ECO:0000269PubMed:11328856}; Single-pass type II membrane protein {ECO:0000269PubMed:11328856}. Note=A secreted form produced by proteolytic cleavage may also exist. {ECO:0000305}.

Disease Associations

Tissue Specificity

Predominantly expressed in ovary, testis and prostate. {ECO:0000269PubMed:9988691}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0000003	reproduction
GO:0006508	proteolysis

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005622	intracellular
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR001818 Peptidase M10, metallopeptidase
IPR003582 ShKT domain
IPR003599 Immunoglobulin subtype
IPR006026 Peptidase, metallopeptidase
IPR007110 Immunoglobulin-like domain
IPR021190 Peptidase M10A

PFAM

PF00413
PF01549

PRINTS

PR00138

PIRSF

SMART

SM00254
SM00409
SM00235

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt