Version 5.4
Homo sapiens Protein: ZDHHC9
Summary
InnateDB Protein IDBP-85721.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZDHHC9
Protein Name zinc finger, DHHC-type containing 9
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000360103
InnateDB Gene IDBG-85713 (ZDHHC9)
Protein Structure
UniProt Annotation
Function The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. {ECO:0000269PubMed:16000296}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:16000296}; Multi-pass membrane protein {ECO:0000269PubMed:16000296}. Golgi apparatus membrane {ECO:0000269PubMed:16000296}; Multi-pass membrane protein {ECO:0000269PubMed:16000296}.
Disease Associations Mental retardation, X-linked, syndromic, ZDHHC9-related (MRXSZ) [MIM:300799]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Some MRXSZ patients have marfanoid habitus as an additional feature. {ECO:0000269PubMed:17436253, ECO:0000269PubMed:19377476}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Highly expressed in kidney, skeletal muscle, brain, lung and liver. Absent in thymus, spleen and leukocytes. {ECO:0000269PubMed:16000296}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016409 palmitoyltransferase activity
GO:0019706 protein-cysteine S-palmitoyltransferase activity
GO:0043849 Ras palmitoyltransferase activity
Biological Process
GO:0008152 metabolic process
GO:0018230 peptidyl-L-cysteine S-palmitoylation
GO:0018345 protein palmitoylation
Cellular Component
GO:0002178 palmitoyltransferase complex
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0031228 intrinsic component of Golgi membrane
Protein Structure and Domains
PDB ID
InterPro IPR001594 Zinc finger, DHHC-type, palmitoyltransferase
PFAM PF01529
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y397
PhosphoSite PhosphoSite-Q9Y397
TrEMBL Q5JYE8
UniProt Splice Variant
Entrez Gene 51114
UniGene Hs.712158
RefSeq NP_001008223
HUGO HGNC:18475
OMIM 300646
CCDS CCDS35395
HPRD 06759
IMGT
EMBL AB209807 AF151847 AK001424 AK001524 AL034405 AL161962 AL359542 AY358558 AY952881 BC000035 BC003128 BC006200 BC012826 CH471107
GenPept AAD34084 AAH00035 AAH03128 AAH06200 AAH12826 AAQ88922 ACF60379 BAA91683 BAA91740 BAD93044 CAB82308 CAI42069 CAI42905 EAX11823 EAX11824 EAX11825

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca