InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BIRC7

Summary

InnateDB Protein

IDBP-85848.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BIRC7

Protein Name

baculoviral IAP repeat containing 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000217169

InnateDB Gene

IDBG-85846 (BIRC7)

Protein Structure

UniProt Annotation

Function

Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing. {ECO:0000269PubMed:11084335, ECO:0000269PubMed:16729033, ECO:0000269PubMed:17294084, ECO:0000269PubMed:18034418}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17294084}. Cytoplasm {ECO:0000269PubMed:17294084}. Golgi apparatus {ECO:0000269PubMed:17294084}. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019899	enzyme binding

Biological Process

GO:0006915	apoptotic process
GO:0007257	activation of JUN kinase activity
GO:0010951	negative regulation of endopeptidase activity
GO:0016567	protein ubiquitination
GO:0042127	regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0070247	regulation of natural killer cell apoptotic process