Homo sapiens Protein: BIRC7 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-85852.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | BIRC7 | ||||||||||||||||||||||
Protein Name | baculoviral IAP repeat containing 7 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000345213 | ||||||||||||||||||||||
InnateDB Gene | IDBG-85846 (BIRC7) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing. {ECO:0000269PubMed:11084335, ECO:0000269PubMed:16729033, ECO:0000269PubMed:17294084, ECO:0000269PubMed:18034418}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000269PubMed:17294084}. Cytoplasm {ECO:0000269PubMed:17294084}. Golgi apparatus {ECO:0000269PubMed:17294084}. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR001370
Baculoviral inhibition of apoptosis protein repeat IPR001841 Zinc finger, RING-type |
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PFAM |
PF00653
PF13639 PF14634 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00238
SM00184 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q96CA5 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q96CA5 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 79444 | ||||||||||||||||||||||
UniGene | Hs.256126 | ||||||||||||||||||||||
RefSeq | NP_071444 | ||||||||||||||||||||||
HUGO | HGNC:13702 | ||||||||||||||||||||||
OMIM | 605737 | ||||||||||||||||||||||
CCDS | CCDS13512 | ||||||||||||||||||||||
HPRD | 05761 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF301009 AF311388 AJ309298 AL121827 AY358835 AY358836 BC014475 | ||||||||||||||||||||||
GenPept | AAG33622 AAG37878 AAH14475 AAQ89194 AAQ89195 CAC37337 CAC37338 | ||||||||||||||||||||||