InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GOT1

Summary

InnateDB Protein

IDBP-86018.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GOT1

Protein Name

glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)

Synonyms

ASTQTL1; cAspAT; cCAT; GIG18;

Species

Homo sapiens

Ensembl Protein

ENSP00000359539

InnateDB Gene

IDBG-86016 (GOT1)

Protein Structure

UniProt Annotation

Function

Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. {ECO:0000269PubMed:16039064}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:1974457}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	14 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity
GO:0004609	phosphatidylserine decarboxylase activity
GO:0008483	transaminase activity
GO:0030170	pyridoxal phosphate binding
GO:0031406	carboxylic acid binding
GO:0047801	L-cysteine:2-oxoglutarate aminotransferase activity
GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006103	2-oxoglutarate metabolic process
GO:0006107	oxaloacetate metabolic process
GO:0006114	glycerol biosynthetic process
GO:0006531	aspartate metabolic process
GO:0006532	aspartate biosynthetic process
GO:0006533	aspartate catabolic process
GO:0006536	glutamate metabolic process
GO:0006595	polyamine metabolic process
GO:0008652	cellular amino acid biosynthetic process
GO:0009058	biosynthetic process
GO:0019509	L-methionine biosynthetic process from methylthioadenosine
GO:0019550	glutamate catabolic process to aspartate
GO:0019551	glutamate catabolic process to 2-oxoglutarate
GO:0032869	cellular response to insulin stimulus
GO:0034641	cellular nitrogen compound metabolic process
GO:0043648	dicarboxylic acid metabolic process
GO:0044281	small molecule metabolic process
GO:0051384	response to glucocorticoid
GO:0055089	fatty acid homeostasis