InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GOT1

Summary

InnateDB Gene

IDBG-86016.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GOT1

Gene Name

glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)

Synonyms

ASTQTL1; cAspAT; cCAT; GIG18

Species

Homo sapiens

Ensembl Gene

ENSG00000120053

Encoded Proteins

IDBP-86018

glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:99396870-99430624

Strand

Reverse strand

Band

q24.2

Transcripts

ENST00000370508	ENSP00000359539
ENST00000489349
ENST00000471741

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	14 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity
GO:0004609	phosphatidylserine decarboxylase activity
GO:0008483	transaminase activity
GO:0030170	pyridoxal phosphate binding
GO:0031406	carboxylic acid binding
GO:0047801	L-cysteine:2-oxoglutarate aminotransferase activity
GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006103	2-oxoglutarate metabolic process
GO:0006107	oxaloacetate metabolic process
GO:0006114	glycerol biosynthetic process
GO:0006531	aspartate metabolic process
GO:0006532	aspartate biosynthetic process
GO:0006533	aspartate catabolic process
GO:0006536	glutamate metabolic process
GO:0006595	polyamine metabolic process
GO:0008652	cellular amino acid biosynthetic process
GO:0009058	biosynthetic process
GO:0019509	L-methionine biosynthetic process from methylthioadenosine
GO:0019550	glutamate catabolic process to aspartate
GO:0019551	glutamate catabolic process to 2-oxoglutarate
GO:0032869	cellular response to insulin stimulus
GO:0034641	cellular nitrogen compound metabolic process
GO:0043648	dicarboxylic acid metabolic process
GO:0044281	small molecule metabolic process
GO:0051384	response to glucocorticoid
GO:0055089	fatty acid homeostasis