InnateDB Protein
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IDBP-862.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CXADR
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Protein Name
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coxsackie virus and adenovirus receptor
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Synonyms
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CAR; CAR4/6; HCAR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000348620
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InnateDB Gene
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IDBG-854 (CXADR)
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Protein Structure
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Function |
Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. {ECO:0000269PubMed:11734628, ECO:0000269PubMed:12297051, ECO:0000269PubMed:15800062, ECO:0000269PubMed:19064666, ECO:0000269PubMed:9096397}.
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Subcellular Localization |
Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Basolateral cell membrane; Single-pass type I membrane protein. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface.Isoform 2: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Basolateral cell membrane; Single-pass membrane protein. Note=In epithelial cells localizes to the apical junction complex composced of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface.Isoform 3: Secreted.Isoform 4: Secreted.Isoform 5: Secreted.
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Disease Associations |
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Tissue Specificity |
Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy. {ECO:0000269PubMed:10490761, ECO:0000269PubMed:11457744, ECO:0000269PubMed:11549277, ECO:0000269PubMed:9096397}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P78310
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PhosphoSite |
PhosphoSite-P78310
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1525
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UniGene |
Hs.738988
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RefSeq |
NP_001193994
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HUGO |
HGNC:2559
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OMIM |
602621
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CCDS |
CCDS56207
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HPRD |
11804
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IMGT |
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EMBL |
AF124598
AF169360
AF169361
AF169362
AF169363
AF169364
AF169365
AF169366
AF200465
AF242862
AF242864
AF242865
AK313526
AP000963
AP000967
AY072910
AY072911
AY072912
BC003684
BC010536
BT019876
CH471079
CR617256
GU474812
U90716
Y07593
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GenPept |
AAC51234
AAD31772
AAF05908
AAF24344
AAG01088
AAH03684
AAH10536
AAL68878
AAL68879
AAL68880
AAV38679
ADC84500
BAG36305
CAA68868
EAX10031
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