Version 5.4
Homo sapiens Gene: CXADR
Summary
InnateDB Gene IDBG-854.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXADR
Gene Name coxsackie virus and adenovirus receptor
Synonyms CAR; CAR4/6; HCAR
Species Homo sapiens
Ensembl Gene ENSG00000154639
Encoded Proteins
IDBP-856
coxsackie virus and adenovirus receptor
IDBP-862
coxsackie virus and adenovirus receptor
IDBP-228876
coxsackie virus and adenovirus receptor
IDBP-228878
coxsackie virus and adenovirus receptor
IDBP-228880
coxsackie virus and adenovirus receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:17512382-17593579
Strand Forward strand
Band q21.1
Transcripts
ENST00000284878 ENSP00000284878
ENST00000356275 ENSP00000348620
ENST00000400169 ENSP00000383033
ENST00000400166 ENSP00000383030
ENST00000400165 ENSP00000383029
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0005102 receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0030165 PDZ domain binding
GO:0042802 identical protein binding
GO:0050839 cell adhesion molecule binding
GO:0071253 connexin binding
Biological Process
GO:0007005 mitochondrion organization
GO:0007157 heterophilic cell-cell adhesion
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0008354 germ cell migration
GO:0009615 response to virus
GO:0010669 epithelial structure maintenance
GO:0016032 viral process
GO:0030593 neutrophil chemotaxis
GO:0031532 actin cytoskeleton reorganization
GO:0034109 homotypic cell-cell adhesion
GO:0045216 cell-cell junction organization
GO:0046629 gamma-delta T cell activation
GO:0048739 cardiac muscle fiber development
GO:0050776 regulation of immune response
GO:0050900 leukocyte migration
GO:0051607 defense response to virus
GO:0070633 transepithelial transport
GO:0086067 AV node cell to bundle of His cell communication
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005923 tight junction
GO:0014704 intercalated disc
GO:0016323 basolateral plasma membrane
GO:0016327 apicolateral plasma membrane
GO:0030054 cell junction
GO:0030175 filopodium
GO:0030426 growth cone
GO:0031594 neuromuscular junction
GO:0043005 neuron projection
GO:0043234 protein complex
GO:0044297 cell body
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022865
View Gene Order
ENSBTAG00000004869
Not yet available
Pathways
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
hsa05416
Viral myocarditis pathway
INOH
PID NCI
Cross-References
SwissProt P78310
TrEMBL
UniProt Splice Variant
Entrez Gene 1525
UniGene Hs.600232 Hs.609118 Hs.627078 Hs.738988
RefSeq NM_001207064 NM_001207063 NM_001207065 NM_001207066 NM_001338
HUGO HGNC:2559
OMIM 602621
CCDS CCDS56206 CCDS33519 CCDS56204 CCDS56205 CCDS56207
HPRD 11804
IMGT
EMBL AF124598 AF169360 AF169361 AF169362 AF169363 AF169364 AF169365 AF169366 AF200465 AF242862 AF242864 AF242865 AK313526 AP000963 AP000967 AY072910 AY072911 AY072912 BC003684 BC010536 BT019876 CH471079 CR617256 GU474812 U90716 Y07593
GenPept AAC51234 AAD31772 AAF05908 AAF24344 AAG01088 AAH03684 AAH10536 AAL68878 AAL68879 AAL68880 AAV38679 ADC84500 BAG36305 CAA68868 EAX10031
RNA Seq Atlas 1525

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca