InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TOR2A

Summary

InnateDB Protein

IDBP-86346.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOR2A

Protein Name

torsin family 2, member A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362381

InnateDB Gene

IDBG-86344 (TOR2A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed ubiquitously, except in cardiac and endothelial tissues. {ECO:0000269PubMed:12910263}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0051260	protein homooligomerization

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen

Protein Structure and Domains

PDB ID

InterPro

IPR001270 ClpA/B family
IPR003593 AAA+ ATPase domain
IPR010448 Torsin
IPR017378 Torsin, subgroup
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF06309

PRINTS

PR00300

PIRSF

PIRSF038079

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5JU69

PhosphoSite

PhosphoSite-Q5JU69

TrEMBL

UniProt Splice Variant

Entrez Gene

27433

UniGene

Hs.444106

RefSeq

NP_001238950

HUGO

HGNC:11996

OMIM

608052

CCDS

CCDS43879

HPRD

16271

IMGT

EMBL

AK027677 AL162426 AY358180 BC080527 BC100907 BC100908 BC100909 BC100910

GenPept

AAH80527 AAI00908 AAI00909 AAI00910 AAI00911 AAQ88547 BAB55288 CAI41186 CAI41187