Version 5.4
Homo sapiens Gene: TOR2A
Summary
InnateDB Gene IDBG-86344.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOR2A
Gene Name torsin family 2, member A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000160404
Encoded Proteins
IDBP-86346
torsin family 2, member A
IDBP-86348
torsin family 2, member A
IDBP-86352
torsin family 2, member A
IDBP-812053
torsin family 2, member A
IDBP-812056
torsin family 2, member A
IDBP-812058
torsin family 2, member A
IDBP-812060
torsin family 2, member A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the AAA family of adenosine triphosphatases with similarity to Clp proteases and heat shock proteins. Alternative splicing at this locus results in the translation of multiple isoforms of the encoded protein, some of which contain salusin peptides in the C-terminal region. These peptides may play roles in hypotension, myocardial growth and the induction of mitogenesis, and may also be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:127731524-127735317
Strand Reverse strand
Band q34.11
Transcripts
ENST00000373284 ENSP00000362381
ENST00000373281 ENSP00000362378
ENST00000336067 ENSP00000338317
ENST00000463577 ENSP00000485268
ENST00000472723
ENST00000463256 ENSP00000485648
ENST00000496460 ENSP00000485544
ENST00000494135
ENST00000493439 ENSP00000485360
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0051085 chaperone mediated protein folding requiring cofactor
GO:0051260 protein homooligomerization
Cellular Component
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000009563
View Gene Order
ENSBTAG00000013510
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444106
RefSeq NM_001085347 NM_001134430 NM_001134431 NM_130459
HUGO
OMIM
CCDS CCDS43879 CCDS48024 CCDS6876
HPRD 16271
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca