Version 5.4
Homo sapiens Protein: TOR2A
Summary
InnateDB Protein IDBP-86352.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOR2A
Protein Name torsin family 2, member A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000338317
InnateDB Gene IDBG-86344 (TOR2A)
Protein Structure
UniProt Annotation
Function Salusins -alpha and -beta may be endocrine and/or paracrine factors able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusins may also be potent hypotensive peptides. {ECO:0000269PubMed:12910263}.
Subcellular Localization Secreted {ECO:0000269PubMed:12910263}.
Disease Associations
Tissue Specificity Isoform 4 is ubiquitously expressed, with high level in vascular endothelial cells and vascular smooth muscle cells. {ECO:0000269PubMed:12910263}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005524 ATP binding
Biological Process
GO:0051085 chaperone mediated protein folding requiring cofactor
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR010448 Torsin
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF06309
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N2E6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 27433
UniGene Hs.444106
RefSeq NP_001238952
HUGO HGNC:11996
OMIM 608052
CCDS CCDS48024
HPRD 16271
IMGT
EMBL AK075520 AL162426
GenPept BAC11667 CAI41185

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca