InnateDB Protein
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IDBP-86495.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NFYA
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Protein Name
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nuclear transcription factor Y, alpha
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Synonyms
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CBF-A; CBF-B; HAP2; NF-YA;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000229418
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InnateDB Gene
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IDBG-86491 (NFYA)
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Protein Structure
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Function |
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1. {ECO:0000269PubMed:12741956}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
51
[view]
|
Protein-Protein |
39
[view]
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Protein-DNA |
12
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
GO:0006355
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regulation of transcription, DNA-templated
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0044255
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cellular lipid metabolic process
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GO:0044281
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small molecule metabolic process
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GO:0045893
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positive regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
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InterPro |
IPR001289
CCAAT-binding transcription factor, subunit B
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PFAM |
PF02045
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PRINTS |
PR00616
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PIRSF |
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SMART |
SM00521
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TIGRFAMs |
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Modification |
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SwissProt |
P23511
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PhosphoSite |
PhosphoSite-P23511
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TrEMBL |
A0A024RD22
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UniProt Splice Variant |
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Entrez Gene |
4800
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UniGene |
Hs.602747
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RefSeq |
NP_068351
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HUGO |
HGNC:7804
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OMIM |
189903
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CCDS |
CCDS4850
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HPRD |
01793
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IMGT |
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EMBL |
AL031778
BC039244
CH471081
M59079
X59711
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GenPept |
AAA35950
AAH39244
CAA42231
CAB44743
CAI20286
EAX04013
EAX04016
EAX04019
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