InnateDB Protein
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IDBP-8652.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPIP5K1
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Protein Name
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diphosphoinositol pentakisphosphate kinase 1
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Synonyms
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HISPPD2A; hsVIP1; IP6K; IPS1; VIP1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000334779
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InnateDB Gene
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IDBG-8646 (PPIP5K1)
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Protein Structure
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Function |
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis- diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269PubMed:17412958, ECO:0000269PubMed:17690096, ECO:0000269PubMed:17702752}.
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Subcellular Localization |
Cytoplasm, cytosol. Cell membrane. Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway.
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Disease Associations |
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Tissue Specificity |
Widely expressed, with a higher expression in skeletal muscle, heart and brain. {ECO:0000269PubMed:17690096}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0000827
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inositol-1,3,4,5,6-pentakisphosphate kinase activity
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GO:0000832
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inositol hexakisphosphate 5-kinase activity
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GO:0003993
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acid phosphatase activity
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GO:0005524
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ATP binding
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GO:0033857
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diphosphoinositol-pentakisphosphate kinase activity
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GO:0052723
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inositol hexakisphosphate 1-kinase activity
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GO:0052724
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inositol hexakisphosphate 3-kinase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000560
Histidine phosphatase superfamily, clade-2
IPR009069
Cysteine alpha-hairpin motif superfamily
IPR029033
Histidine phosphatase superfamily
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PFAM |
PF00328
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6PFW1
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PhosphoSite |
PhosphoSite-Q6PFW1
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TrEMBL |
C9JZX6
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UniProt Splice Variant |
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Entrez Gene |
9677
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UniGene |
Hs.739148
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RefSeq |
NP_001124331
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HUGO |
HGNC:29023
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OMIM |
610979
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CCDS |
CCDS32215
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HPRD |
13798
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IMGT |
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EMBL |
AB002375
AC011330
AC019011
AF502586
AF502587
AF502588
AF502589
AF543190
BC050263
BC057395
BX538022
BX647814
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GenPept |
AAH50263
AAH57395
AAN40768
AAP30842
AAP30843
AAP30844
AAP30845
BAA20831
CAD97968
CAI46011
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