Version 5.4
Homo sapiens Gene: PPIP5K1
Summary
InnateDB Gene IDBG-8646.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPIP5K1
Gene Name diphosphoinositol pentakisphosphate kinase 1
Synonyms HISPPD2A; hsVIP1; IP6K; IPS1; VIP1
Species Homo sapiens
Ensembl Gene ENSG00000168781
Encoded Proteins
IDBP-8652
diphosphoinositol pentakisphosphate kinase 1
IDBP-8654
diphosphoinositol pentakisphosphate kinase 1
IDBP-8656
diphosphoinositol pentakisphosphate kinase 1
IDBP-8658
diphosphoinositol pentakisphosphate kinase 1
IDBP-8660
diphosphoinositol pentakisphosphate kinase 1
IDBP-8664
diphosphoinositol pentakisphosphate kinase 1
IDBP-236420
diphosphoinositol pentakisphosphate kinase 1
IDBP-369964
diphosphoinositol pentakisphosphate kinase 1
IDBP-369975
diphosphoinositol pentakisphosphate kinase 1
IDBP-369981
diphosphoinositol pentakisphosphate kinase 1
IDBP-369983
diphosphoinositol pentakisphosphate kinase 1
IDBP-369987
diphosphoinositol pentakisphosphate kinase 1
IDBP-369991
diphosphoinositol pentakisphosphate kinase 1
IDBP-369994
diphosphoinositol pentakisphosphate kinase 1
IDBP-369996
diphosphoinositol pentakisphosphate kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:43533462-43590253
Strand Reverse strand
Band q15.3
Transcripts
ENST00000334933 ENSP00000334779
ENST00000360301 ENSP00000353446
ENST00000360135 ENSP00000353253
ENST00000381885 ENSP00000371309
ENST00000381879 ENSP00000371303
ENST00000348806 ENSP00000308773
ENST00000396923 ENSP00000380129
ENST00000420765 ENSP00000400887
ENST00000439195 ENSP00000387999
ENST00000437065 ENSP00000410563
ENST00000427877 ENSP00000415349
ENST00000453080 ENSP00000407704
ENST00000417085 ENSP00000390657
ENST00000429176 ENSP00000405106
ENST00000431962 ENSP00000405200
ENST00000432870
ENST00000488490
ENST00000462136
ENST00000488768
ENST00000469229
ENST00000465123
ENST00000476294
ENST00000472547
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0000832 inositol hexakisphosphate 5-kinase activity
GO:0003993 acid phosphatase activity
GO:0005524 ATP binding
GO:0033857 diphosphoinositol-pentakisphosphate kinase activity
GO:0052723 inositol hexakisphosphate 1-kinase activity
GO:0052724 inositol hexakisphosphate 3-kinase activity
Biological Process
GO:0006020 inositol metabolic process
GO:0016310 phosphorylation
GO:0016311 dephosphorylation
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033526
View Gene Order
ENSBTAG00000014005
Not yet available
Pathways
NETPATH
REACTOME
REACT_150188
Synthesis of pyrophosphates in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.156814 Hs.739148
RefSeq NM_001130858 NM_001130859 NM_001190214 NM_014659 XM_005254803 XM_005254804
HUGO
OMIM
CCDS CCDS32215 CCDS45252 CCDS53937
HPRD 13798
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca