InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGEF16

Summary

InnateDB Protein

IDBP-86598.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF16

Protein Name

Rho guanine nucleotide exchange factor (GEF) 16

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000367624

InnateDB Gene

IDBG-86592 (ARHGEF16)

Protein Structure

UniProt Annotation

Function

Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269PubMed:20679435}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0017048	Rho GTPase binding
GO:0030165	PDZ domain binding
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0032863	activation of Rac GTPase activity
GO:0032864	activation of Cdc42 GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0060326	cell chemotaxis
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:0097190	apoptotic signaling pathway