InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HIF1AN

Summary

InnateDB Protein

IDBP-86615.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIF1AN

Protein Name

hypoxia inducible factor 1, alpha subunit inhibitor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000299163

InnateDB Gene

IDBG-86613 (HIF1AN)

Protein Structure

UniProt Annotation

Function

Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. {ECO:0000269PubMed:12042299, ECO:0000269PubMed:12080085, ECO:0000269PubMed:17003112, ECO:0000269PubMed:17573339, ECO:0000269PubMed:18299578, ECO:0000269PubMed:19245366, ECO:0000269PubMed:21177872, ECO:0000269PubMed:21251231}.

Subcellular Localization

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	45 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019826	oxygen sensor activity
GO:0031406	carboxylic acid binding
GO:0036139	peptidyl-histidine dioxygenase activity
GO:0036140	peptidyl-asparagine 3-dioxygenase activity
GO:0042803	protein homodimerization activity
GO:0048037	cofactor binding
GO:0051059	NF-kappaB binding
GO:0071532	ankyrin repeat binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0036138	peptidyl-histidine hydroxylation
GO:0042264	peptidyl-aspartic acid hydroxylation
GO:0042265	peptidyl-asparagine hydroxylation
GO:0045087	innate immune response (InnateDB)
GO:0045663	positive regulation of myoblast differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0055114	oxidation-reduction process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456	cellular response to hypoxia
GO:2001214	positive regulation of vasculogenesis