InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPIP5K1

Summary

InnateDB Protein

IDBP-8664.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPIP5K1

Protein Name

diphosphoinositol pentakisphosphate kinase 1

Synonyms

HISPPD2A; hsVIP1; IP6K; IPS1; VIP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000308773

InnateDB Gene

IDBG-8646 (PPIP5K1)

Protein Structure

UniProt Annotation

Function

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis- diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269PubMed:17412958, ECO:0000269PubMed:17690096, ECO:0000269PubMed:17702752}.

Subcellular Localization

Cytoplasm, cytosol. Cell membrane. Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway.

Disease Associations

Tissue Specificity

Widely expressed, with a higher expression in skeletal muscle, heart and brain. {ECO:0000269PubMed:17690096}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000827	inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0000832	inositol hexakisphosphate 5-kinase activity
GO:0003993	acid phosphatase activity
GO:0005524	ATP binding
GO:0033857	diphosphoinositol-pentakisphosphate kinase activity
GO:0052723	inositol hexakisphosphate 1-kinase activity
GO:0052724	inositol hexakisphosphate 3-kinase activity

Biological Process

GO:0006020	inositol metabolic process
GO:0016310	phosphorylation
GO:0016311	dephosphorylation
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process