Version 5.4
Homo sapiens Protein: NCR2
Summary
InnateDB Protein IDBP-86658.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCR2
Protein Name natural cytotoxicity triggering receptor 2
Synonyms CD336; dJ149M18.1; LY95; NK-p44; NKP44;
Species Homo sapiens
Ensembl Protein ENSP00000362181
InnateDB Gene IDBG-86656 (NCR2)
Protein Structure
UniProt Annotation
Function Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. {ECO:0000269PubMed:10049942}.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells. {ECO:0000269PubMed:10049942}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
Biological Process
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0045087 innate immune response
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95944
PhosphoSite PhosphoSite-O95944
TrEMBL
UniProt Splice Variant
Entrez Gene 9436
UniGene Hs.194721
RefSeq NP_004819
HUGO HGNC:6732
OMIM 604531
CCDS CCDS4855
HPRD 05168
IMGT
EMBL AJ010099 AJ010100 AJ225109 AL136967
GenPept CAB39168 CAB52289 CAB52290 CAC09452 CAC09453 CAC09454

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca