InnateDB Protein
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IDBP-86667.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FOXP4
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Protein Name
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forkhead box P4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000362151
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InnateDB Gene
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IDBG-86663 (FOXP4)
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Protein Structure
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|
Function |
Transcriptional repressor that represses lung-specific expression. {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00089}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
|
Protein-Protein |
8
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001078
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0042803
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protein homodimerization activity
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GO:0043565
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sequence-specific DNA binding
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GO:0046872
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metal ion binding
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GO:0046982
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protein heterodimerization activity
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0007507
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heart development
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GO:0048617
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embryonic foregut morphogenesis
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GO:0061140
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lung secretory cell differentiation
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GO:1901249
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regulation of lung goblet cell differentiation
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GO:1901250
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negative regulation of lung goblet cell differentiation
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Cellular Component |
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PDB ID |
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InterPro |
IPR001766
Transcription factor, fork head
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PFAM |
PF00250
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PRINTS |
PR00053
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PIRSF |
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SMART |
SM00339
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IVH2
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PhosphoSite |
PhosphoSite-Q8IVH2
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TrEMBL |
Q8N4A5
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UniProt Splice Variant |
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Entrez Gene |
116113
|
UniGene |
Hs.603717
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RefSeq |
NP_001012426
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HUGO |
HGNC:20842
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OMIM |
608924
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CCDS |
CCDS34447
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HPRD |
10600
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IMGT |
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EMBL |
AB080747
AL139331
AL832437
BC013030
BC034931
BC040962
BC052803
CH471081
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GenPept |
AAH13030
AAH34931
AAH40962
AAH52803
BAC53809
CAH10652
CAH72540
CAH72541
CAH72542
EAX04047
EAX04048
EAX04049
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