Version 5.4
Homo sapiens Gene: FOXP4
Summary
InnateDB Gene IDBG-86663.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXP4
Gene Name forkhead box P4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137166
Encoded Proteins
IDBP-86665
forkhead box P4
IDBP-86667
forkhead box P4
IDBP-86671
forkhead box P4
IDBP-86673
forkhead box P4
IDBP-295032
forkhead box P4
IDBP-378274
forkhead box P4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:41546426-41602384
Strand Forward strand
Band p21.1
Transcripts
ENST00000373063 ENSP00000362154
ENST00000373060 ENSP00000362151
ENST00000373057 ENSP00000362148
ENST00000307972 ENSP00000309823
ENST00000409208 ENSP00000386958
ENST00000451305 ENSP00000393704
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007507 heart development
GO:0048617 embryonic foregut morphogenesis
GO:0061140 lung secretory cell differentiation
GO:1901249 regulation of lung goblet cell differentiation
GO:1901250 negative regulation of lung goblet cell differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023991
View Gene Order
ENSBTAG00000014211
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.131436 Hs.603717
RefSeq NM_001012426 NM_001012427 NM_138457 XM_006714991 XM_006714992 XM_006714993 XM_006714994 XM_006714995
HUGO
OMIM
CCDS CCDS34447 CCDS34448 CCDS4856
HPRD 10600
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca