InnateDB Protein
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IDBP-86751.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MDFI
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Protein Name
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MyoD family inhibitor
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Synonyms
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I-MF; I-mfa;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000230321
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InnateDB Gene
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IDBG-86745 (MDFI)
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Protein Structure
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Function |
Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 165 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
165
[view]
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Protein-Protein |
163
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0007257
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activation of JUN kinase activity
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GO:0009790
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embryo development
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GO:0009950
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dorsal/ventral axis specification
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GO:0030111
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regulation of Wnt signaling pathway
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GO:0030178
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negative regulation of Wnt signaling pathway
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GO:0042994
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cytoplasmic sequestering of transcription factor
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GO:0043392
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negative regulation of DNA binding
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GO:0048704
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embryonic skeletal system morphogenesis
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GO:0060707
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trophoblast giant cell differentiation
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99750
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PhosphoSite |
PhosphoSite-Q99750
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TrEMBL |
B1AKC1
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UniProt Splice Variant |
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Entrez Gene |
4188
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UniGene |
Hs.520119
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RefSeq |
NP_005577
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HUGO |
HGNC:6967
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OMIM |
604971
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CCDS |
CCDS4857
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HPRD |
07280
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IMGT |
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EMBL |
AL035588
BC007836
CH471081
U78313
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GenPept |
AAB39748
AAH07836
CAB54148
EAX04051
EAX04052
EAX04053
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