InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TP73

Summary

InnateDB Protein

IDBP-86767.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TP73

Protein Name

tumor protein p73

Synonyms

P73;

Species

Homo sapiens

Ensembl Protein

ENSP00000367539

InnateDB Gene

IDBG-86757 (TP73)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 160 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	160 [view]
Protein-Protein	144 [view]
Protein-DNA	16 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003682	chromatin binding
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006298	mismatch repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010165	response to X-ray
GO:0010332	response to gamma radiation
GO:0031571	mitotic G1 DNA damage checkpoint
GO:0034644	cellular response to UV
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043508	negative regulation of JUN kinase activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051262	protein tetramerization

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR002117 p53 tumour suppressor family
IPR008967 p53-like transcription factor, DNA-binding
IPR010991 p53, tetramerisation domain
IPR011510 Sterile alpha motif, type 2
IPR011615 p53, DNA-binding domain
IPR013761 Sterile alpha motif/pointed domain

PFAM

PF07710
PF07647
PF00870

PRINTS

PR00386

PIRSF

SMART

SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt