Version 5.4
Homo sapiens Gene: TP73
Summary
InnateDB Gene IDBG-86757.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TP73
Gene Name tumor protein p73
Synonyms P73
Species Homo sapiens
Ensembl Gene ENSG00000078900
Encoded Proteins
IDBP-86759
tumor protein p73
IDBP-86761
tumor protein p73
IDBP-86763
tumor protein p73
IDBP-86765
tumor protein p73
IDBP-86767
tumor protein p73
IDBP-86769
tumor protein p73
IDBP-86771
tumor protein p73
IDBP-86773
tumor protein p73
IDBP-809242
tumor protein p73
IDBP-809244
tumor protein p73
IDBP-809246
tumor protein p73
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22976836
TP73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses. (Demonstrated in mouse)
InnateDB Annotation from Orthologs
Summary
PMID 22976836
[Mus musculus] Trp73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses.
Entrez Gene
Summary This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:3652520-3736201
Strand Forward strand
Band p36.32
Transcripts
ENST00000378295 ENSP00000367545
ENST00000354437 ENSP00000346423
ENST00000357733 ENSP00000350366
ENST00000346387 ENSP00000340740
ENST00000378290 ENSP00000367539
ENST00000378288 ENSP00000367537
ENST00000378285 ENSP00000367534
ENST00000378280 ENSP00000367529
ENST00000604074 ENSP00000475143
ENST00000603362 ENSP00000474626
ENST00000604479 ENSP00000474322
ENST00000603364
ENST00000604194
ENST00000604566
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 160 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 160 [view]
Protein-Protein 144 [view]
Protein-DNA 16 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000187 activation of MAPK activity
GO:0001822 kidney development
GO:0001836 release of cytochrome c from mitochondria
GO:0006298 mismatch repair
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006954 inflammatory response
GO:0006974 cellular response to DNA damage stimulus
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007050 cell cycle arrest
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009791 post-embryonic development
GO:0010165 response to X-ray
GO:0010243 response to organonitrogen compound
GO:0010332 response to gamma radiation
GO:0021766 hippocampus development
GO:0030900 forebrain development
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0033326 cerebrospinal fluid secretion
GO:0034644 cellular response to UV
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043065 positive regulation of apoptotic process
GO:0043508 negative regulation of JUN kinase activity
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045665 negative regulation of neuron differentiation
GO:0045793 positive regulation of cell size
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048546 digestive tract morphogenesis
GO:0048666 neuron development
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0051262 protein tetramerization
GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029026
View Gene Order
ENSBTAG00000005812
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
p73pathway
p73 transcription factor network
e2f_pathway
E2F transcription factor network
Cross-References
SwissProt O15350
TrEMBL
UniProt Splice Variant
Entrez Gene 7161
UniGene
RefSeq NM_001126240 NM_001126241 NM_001126242 NM_001204184 NM_001204185 NM_001204186 NM_001204187 NM_001204188 NM_001204189 NM_001204190 NM_001204191 NM_001204192 NM_005427
HUGO HGNC:12003
OMIM 601990
CCDS CCDS55567 CCDS44049 CCDS44050 CCDS44051 CCDS49 CCDS55566 CCDS55568 CCDS55569 CCDS59965
HPRD
IMGT
EMBL AB055065 AB055066 AF077616 AF077617 AF077618 AF077619 AF077620 AF077621 AF077624 AF077625 AF077626 AF077627 AF077628 AF079082 AF079083 AF079084 AF079085 AF079086 AF079087 AF079088 AF079089 AF079090 AF079091 AF079092 AF079093 AF079094 AK302118 AK304177 AK304784 AL136528 AY040827 AY040828 AY040829 BC117251 BC117253 CH471130 Y11416
GenPept AAC61887 AAD39696 AAI17252 AAI17254 AAK81884 AAK81885 AAK81886 BAB87244 BAB87245 BAH13630 BAH14127 BAH14257 CAA72219 CAA72220 CAA72221 CAI19123 CAI19124 CAI19125 CAI19126 CAI19127 EAW71464
RNA Seq Atlas 7161

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca