InnateDB Protein
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IDBP-86811.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PHF6
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Protein Name
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PHD finger protein 6
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359836
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InnateDB Gene
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IDBG-86805 (PHF6)
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Protein Structure
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Function |
Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269PubMed:23229552}.
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Subcellular Localization |
Nucleus. Nucleus, nucleolus. Note=Nuclear, it particularly localizes to the nucleolus.
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Disease Associations |
Boerjeson-Forssman-Lehmann syndrome (BFLS) [MIM:301900]: A X-linked recessive disorder characterized by moderate to severe mental retardation, epilepsy, hypogonadism, hypometabolism, obesity with marked gynecomastia, swelling of subcutaneous tissue of the face, narrow palpebral fissure and large but not deformed ears. {ECO:0000269PubMed:12415272}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:12415272}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011011
Zinc finger, FYVE/PHD-type
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IWS0
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PhosphoSite |
PhosphoSite-Q8IWS0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84295
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UniGene |
Hs.629209
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RefSeq |
NP_115711
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HUGO |
HGNC:18145
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OMIM |
300414
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CCDS |
CCDS14640
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HPRD |
02330
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IMGT |
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EMBL |
AB058726
AC004383
AK290095
AK303369
AL591668
AY157622
BC005994
CH471107
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GenPept |
AAH05994
AAO13214
BAB47452
BAF82784
BAG64426
CAI41600
CAI41601
EAX11762
EAX11763
EAX11766
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