InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ST6GALNAC6

Summary

InnateDB Protein

IDBP-86824.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ST6GALNAC6

Protein Name

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362234

InnateDB Gene

IDBG-86814 (ST6GALNAC6)

Protein Structure

UniProt Annotation

Function

Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)). {ECO:0000269PubMed:12668675, ECO:0000269PubMed:17123352}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines. {ECO:0000269PubMed:12668675, ECO:0000269PubMed:17123352}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
GO:0008373	sialyltransferase activity

Biological Process

GO:0001574	ganglioside biosynthetic process
GO:0006486	protein glycosylation
GO:0006677	glycosylceramide metabolic process
GO:0006687	glycosphingolipid metabolic process
GO:0009100	glycoprotein metabolic process
GO:0009312	oligosaccharide biosynthetic process
GO:0009988	cell-cell recognition
GO:0097503	sialylation