Version 5.4
Homo sapiens Gene: ST6GALNAC6
Summary
InnateDB Gene IDBG-86814.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST6GALNAC6
Gene Name ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000160408
Encoded Proteins
IDBP-86816
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
IDBP-86818
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
IDBP-86820
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
IDBP-86822
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
IDBP-86824
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
IDBP-381176
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
IDBP-583386
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
IDBP-809573
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 [PubMed 12668675]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:127885321-127905408
Strand Reverse strand
Band q34.11
Transcripts
ENST00000373146 ENSP00000362239
ENST00000291839 ENSP00000291839
ENST00000373144 ENSP00000362237
ENST00000373142 ENSP00000362235
ENST00000373141 ENSP00000362234
ENST00000447681 ENSP00000405326
ENST00000485320
ENST00000463086
ENST00000480417
ENST00000494541
ENST00000483353
ENST00000481355
ENST00000478319
ENST00000494611
ENST00000542456 ENSP00000438109
ENST00000622357 ENSP00000477575
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0001574 ganglioside biosynthetic process
GO:0006486 protein glycosylation
GO:0006677 glycosylceramide metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0009100 glycoprotein metabolic process
GO:0009312 oligosaccharide biosynthetic process
GO:0009988 cell-cell recognition
GO:0097503 sialylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026811
View Gene Order
ENSBTAG00000044129
Not yet available
Pathways
NETPATH
REACTOME
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_200874
Sialic acid metabolism pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00604
Glycosphingolipid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.109672
RefSeq NM_001286999 NM_001287000 NM_001287001 NM_001287002 NM_001287003 NM_013443 XM_005251952 XM_006717088 XM_006717089 XM_006717090 XM_006717091
HUGO
OMIM
CCDS CCDS6882 CCDS69668 CCDS69669 CCDS75908
HPRD 18111
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca