InnateDB Protein
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IDBP-86855.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TNFRSF6B
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Protein Name
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tumor necrosis factor receptor superfamily, member 6b, decoy
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Synonyms
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DCR3; DJ583P15.1.1; M68; M68E; TR6;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359013
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InnateDB Gene
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IDBG-402658 (TNFRSF6B)
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Protein Structure
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Function |
Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. {ECO:0000269PubMed:21300286}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001368
TNFR/NGFR cysteine-rich region
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PFAM |
PF00020
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PRINTS |
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PIRSF |
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SMART |
SM00208
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TIGRFAMs |
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Modification |
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SwissProt |
O95407
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PhosphoSite |
PhosphoSite-O95407
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TrEMBL |
H0UI95
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UniProt Splice Variant |
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Entrez Gene |
8771
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UniGene |
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RefSeq |
NP_003814
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HUGO |
HGNC:11921
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OMIM |
603361
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CCDS |
CCDS13532
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HPRD |
04527
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IMGT |
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EMBL |
AF104419
AF134240
AF217793
AF217794
AF217796
AL121845
AY358279
BC017065
BC034349
CH471077
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GenPept |
AAD03056
AAD29688
AAF33685
AAF33686
AAF35244
AAH17065
AAH34349
AAQ88646
CAC03668
EAW75247
EAW75248
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