Version 5.4
Homo sapiens Protein: USP49
Summary
InnateDB Protein IDBP-86915.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP49
Protein Name ubiquitin specific peptidase 49
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362100
InnateDB Gene IDBG-86911 (USP49)
Protein Structure
UniProt Annotation
Function Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons. {ECO:0000269PubMed:23824326}.
Subcellular Localization Nucleus {ECO:0000305PubMed:23824326}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0036459 ubiquitinyl hydrolase activity
GO:0042393 histone binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination
GO:0035616 histone H2B conserved C-terminal lysine deubiquitination
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR001607 Zinc finger, UBP-type
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
PFAM PF00443
PF02148
PRINTS
PIRSF
SMART SM00290
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q70CQ1
PhosphoSite PhosphoSite-Q70CQ1
TrEMBL A6PVU2
UniProt Splice Variant
Entrez Gene 25862
UniGene Hs.665742
RefSeq NP_001273483
HUGO HGNC:20078
OMIM
CCDS CCDS69111
HPRD 10075
IMGT
EMBL AJ586139 AL160163 AL365205 BC014176 CH471081
GenPept AAH14176 CAE51939 CAI13187 CAI13188 EAX04065

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca