Version 5.4
Homo sapiens Protein: DFFB
Summary
InnateDB Protein IDBP-86956.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DFFB
Protein Name DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
Synonyms CAD; CPAN; DFF-40; DFF2; DFF40;
Species Homo sapiens
Ensembl Protein ENSP00000367454
InnateDB Gene IDBG-86952 (DFFB)
Protein Structure
UniProt Annotation
Function Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004536 deoxyribonuclease activity
GO:0016787 hydrolase activity
GO:0019899 enzyme binding
Biological Process
GO:0006309 apoptotic DNA fragmentation
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0030263 apoptotic chromosome condensation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR003508 CIDE-N domain
IPR015311 Apoptosis, DNA fragmentation factor 40kDa
PFAM PF02017
PF09230
PRINTS
PIRSF
SMART SM00266
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O76075
PhosphoSite PhosphoSite-O76075
TrEMBL Q96P72
UniProt Splice Variant
Entrez Gene 1677
UniGene Hs.133089
RefSeq NP_004393
HUGO HGNC:2773
OMIM 601883
CCDS CCDS52
HPRD 03532
IMGT
EMBL AB013918 AB028911 AB028912 AB028913 AF039210 AF064019 AF409062 AK290877 AL691523 BC048797
GenPept AAC39709 AAC39920 AAH48797 AAL02007 BAA32250 BAB40447 BAB40448 BAB40449 BAF83566 CAI17371

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca