InnateDB Protein
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IDBP-87016.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TAF8
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Protein Name
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TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000362068
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InnateDB Gene
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IDBG-87010 (TAF8)
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Protein Structure
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Function |
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:14580349}. Cytoplasm {ECO:0000250}. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
33
[view]
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Protein-Protein |
33
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006565
Bromodomain transcription factor
IPR009072
Histone-fold
IPR019473
Transcription factor TFIID, subunit 8, C-terminal
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PFAM |
PF07524
PF10406
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PRINTS |
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PIRSF |
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SMART |
SM00576
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TIGRFAMs |
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Modification |
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SwissProt |
Q7Z7C8
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PhosphoSite |
PhosphoSite-Q7Z7C8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
129685
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UniGene |
Hs.694242
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RefSeq |
NP_612639
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HUGO |
HGNC:17300
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OMIM |
609514
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CCDS |
CCDS43462
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HPRD |
18167
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IMGT |
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EMBL |
AF465841
AK057383
AL512274
AL513008
BC119678
BC119679
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GenPept |
AAI19679
AAI19680
AAP47094
BAB71460
CAI15202
CAI15203
CAI16781
CAI16782
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