InnateDB Protein
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IDBP-87069.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LBX1
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Protein Name
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ladybird homeobox 1
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Synonyms
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homeobox; HPX-6; HPX6; LBX1H;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359212
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InnateDB Gene
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IDBG-87067 (LBX1)
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Protein Structure
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Function |
Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord. {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000976
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transcription regulatory region sequence-specific DNA binding
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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Biological Process |
GO:0001947
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heart looping
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0007517
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muscle organ development
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GO:0008285
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negative regulation of cell proliferation
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GO:0009653
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anatomical structure morphogenesis
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GO:0021522
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spinal cord motor neuron differentiation
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GO:0021920
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regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification
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GO:0045665
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negative regulation of neuron differentiation
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GO:0048663
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neuron fate commitment
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GO:0048664
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neuron fate determination
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Cellular Component |
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PDB ID |
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InterPro |
IPR000047
Helix-turn-helix motif
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
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PFAM |
PF00046
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PRINTS |
PR00031
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PIRSF |
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SMART |
SM00389
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TIGRFAMs |
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Modification |
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SwissProt |
P52954
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q6LBH2
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UniProt Splice Variant |
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Entrez Gene |
10660
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UniGene |
Hs.37128
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RefSeq |
NP_006553
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HUGO |
HGNC:16960
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OMIM |
604255
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CCDS |
CCDS31270
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HPRD |
09178
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IMGT |
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EMBL |
AL135794
BC069156
BC136321
CH471066
X74863
X90828
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GenPept |
AAH69156
AAI36322
CAA52856
CAA62342
CAH72508
EAW49777
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