InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZGPAT

Summary

InnateDB Protein

IDBP-87151.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZGPAT

Protein Name

zinc finger, CCCH-type with G patch domain

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000349634

InnateDB Gene

IDBG-87143 (ZGPAT)

Protein Structure

UniProt Annotation

Function

Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269PubMed:19644445}.Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269PubMed:19644445}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19644445}.Isoform 4: Nucleus {ECO:0000269PubMed:20233718}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:19644445}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
GO:0045892	negative regulation of transcription, DNA-templated