InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRERF1

Summary

InnateDB Protein

IDBP-87185.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRERF1

Protein Name

transcriptional regulating factor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000339438

InnateDB Gene

IDBG-87179 (TRERF1)

Protein Structure

UniProt Annotation

Function

Activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269PubMed:11349124}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00512, ECO:0000255PROSITE-ProRule:PRU00624, ECO:0000269PubMed:11349124}.

Disease Associations

Tissue Specificity

Highest expression was seen in thymus, testis and adrenal cortex, expressed also in the adrenal medulla, thyroid, and stomach. Highly expressed in steroidogenic JEG-3 and MCF-7 cells, low expression was seen in non-steroidogenic Hep-G2 and HEK293 cells. {ECO:0000269PubMed:11349124}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0046872	metal ion binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006694	steroid biosynthetic process
GO:0006707	cholesterol catabolic process
GO:0007275	multicellular organismal development
GO:0042592	homeostatic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046885	regulation of hormone biosynthetic process